Comparative Evaluation of Vezotil and Zoletil
Pilot clinical study • Biocontrol Center
"Biocontrol" Veterinary Oncology Research Center
Russia's leading veterinary oncology center
Research Team
Evgeny A. Kornyushenkov
Lead Researcher, PhD in Veterinary Sciences
Daria V. Vdovina
Veterinary Anesthesiologist
Polina A. Anisimova
Research Associate
Ekaterina V. Viktorova
Statistical Analyst
Study Parameters
Period
Sept 1 - Oct 12, 2023
Duration
42 days
Subjects
28 animals
Groups
16 cats, 12 dogs
Study Methodology
Study Objectives
- • Comparative anesthetic activity assessment
- • Safety and tolerability analysis
- • Anesthesia onset and duration evaluation
- • Recovery quality comparison
- • Adverse reaction monitoring
Inclusion Criteria
- • Healthy animals (ASA I-II)
- • Age 1 to 8 years
- • Body weight 2 to 45 kg
- • Elective surgical procedures
- • Owner consent for participation
Key Results
Therapeutic Equivalence
The study demonstrated therapeutic equivalence of Vezotil® and Zoletil® 100. Both drugs showed comparable efficacy in providing anesthesia for cats and dogs during elective surgical procedures.
Vezotil® Advantages
- More pronounced sedation during induction
- Significantly reduced salivation
- Smoother recovery
- Excellent animal tolerability
Time Parameters
Study Conclusion
Vezotil® demonstrated therapeutic equivalence to Zoletil® 100 across key anesthetic activity parameters. Some advantages of Vezotil were noted in terms of sedative effect and animal comfort.
The study confirmed the safety of Vezotil® use in cats and dogs of various breeds and ages when following recommended dosages and protocols.
🏆 Recommendation: Vezotil® can be considered as an effective alternative to Zoletil® 100 for anesthesia of small companion animals.
Study Protocol
Study Design
Randomized controlled comparative study in parallel groups. Animals were randomly assigned to two groups: Vezotil® group (n=14) and Zoletil® 100 group (n=14).
Administration Protocol
- • Intramuscular administration
- • Dosage: 10-15 mg/kg body weight
- • Atropine premedication
- • Vital function monitoring
Evaluated Parameters
- • Time to sedation onset
- • Anesthesia depth
- • Duration of action
- • Recovery quality
- • Adverse reactions
About "Biocontrol" Center
"Biocontrol" Veterinary Oncology Research Center is a leading institution in veterinary oncology and anesthesiology in Russia. The center specializes in treating oncological diseases in animals and conducting scientific research.
Specializations:
- • Veterinary oncology
- • Anesthesiology and critical care
- • Clinical research
- • Scientific development
Contact Information
Address:
Moscow, Akademika Skryabina St.
Research Department:
research@biocontrol.ru
Collaboration:
Open for scientific collaboration