The authors compared signs of pain after TPLO in patients whose anesthetic care included Vezotil® and in a control group. Vezotil® was administered intravenously during the perioperative period as part of multimodal anesthesia.

• The study included 64 animals: 34 in the Vezotil® group and 30 in the control group.
• Signs of chronic pain were recorded in 4 of 30 dogs in the Vezotil® group and 24 of 27 dogs in the control group.
• Among cats, signs of pain were recorded in 2 of 4 and 3 of 3 animals, respectively; this subgroup is very small.

The findings relate to this specific perioperative protocol and subsequent follow-up. The article does not examine daily Vezotil® administration over days or weeks and does not establish a regimen for long-term treatment of chronic pain.