Comparative Drug Evaluation
Vezotil® vs Zoletil® 100 in Clinical Anesthesiological Practice
Comparative Clinical Evaluation
Comprehensive efficacy and safety comparison • 2024
Study Objective
To conduct comprehensive comparative evaluation of clinical efficacy, safety and tolerability of new Russian drug Vezotil® compared to reference drug Zoletil® 100 during anesthesia in dogs and cats under veterinary clinical practice conditions.
Main Evaluation Parameters
- • Speed of anesthesia onset
- • Anesthesia depth and quality
- • Emergence and recovery time
- • Recovery quality
- • Side effects and complications
- • Hemodynamic parameters
- • Respiratory functions
Key Vezotil® Advantages
- • Faster onset of action
- • Improved emergence quality
- • Reduced salivation
- • Stable hemodynamics
- • Lower side effect frequency
- • Better procedure tolerability
- • Cost effectiveness
Results and Conclusions
Statistically Significant Results
Time parameters:
- • Anesthesia onset: 3-5 min vs 5-7 min
- • Recovery time: 15-20 min vs 20-25 min
- • Full emergence: 25-30 min vs 35-40 min
- • Induction quality: improved by 23%
Safety parameters:
- • Salivation reduced by 35%
- • Apnea reduced by 28%
- • HR stability: +18% compared
- • No serious complications
Clinical Conclusion
Vezotil® demonstrated not only comparable efficacy to Zoletil® 100, but also superiority in a number of important clinical parameters. Particularly notable are improvements in induction and emergence quality, as well as significant reduction in adverse side effects.
✅ Conclusion: Vezotil® is recommended as a safe and effective alternative to the original drug with potential advantages in clinical practice.