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Additional review of the Vezotil® and Zoletil® comparison

Pilot clinical study of anesthetic activity

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Pilot comparative clinical study of the anesthetic activity of the new domestic tiletamine-zolazepam drug Vezotil® and its original counterpart Zoletil® 100

E.A. Kornyushenkov, D.V. Vdovina, P.A. Anisimova, A.A. Shimshirt, E.V. Viktorova · Russian Veterinary Journal, No. 1/2024, pp. 5–11 · DOI 10.32416/2500-4379-2024-1-5-11

Participants

28 dogs and cats

Groups

16 patients received Vezotil®; 12 received Zoletil® 100

Site

Biocontrol Veterinary Clinic

Study design and administration

The article describes a pilot comparison of the two drugs as part of anesthesia for surgical procedures. Vezotil® and Zoletil® 100 were administered intravenously alongside other protocol components, including propofol and isoflurane. The article does not describe randomization or double blinding.

Authors’ observations

  • The authors report more pronounced sedation and less salivation with Vezotil®.
  • Recovery was longer in cats in the Vezotil® group, reaching 300–360 minutes in some cases.
  • A decrease in blood pressure was observed in both groups; one cat required vasopressor support.

Limitations

The sample is small, so these observations should not be presented as proof of superiority or statistically established equivalence. The article does not provide percentage differences, p-values, or a power calculation.