Pilot Comparative Clinical Study
Veterinary Anesthesiology • 2025
Study Authors
E.A. Kornyushenkov
Lead Researcher, PhD in Veterinary Sciences
D.V. Vdovina
Veterinary Anesthesiologist
P.A. Anisimova
Research Associate
A.A. Shimshirt
Statistician
E.V. Viktorova
Data Analyst
Publication Data
Publication Date
May 20, 2025
Journal
Veterinary Anesthesiology
Article Type
Clinical Study
Status
Published
Abstract
This pilot study represents the first comprehensive comparison of anesthetic activity of new domestic drug Vezotil® with its original analog Zoletil® 100. The study was conducted to assess therapeutic equivalence and identify potential advantages of the Russian analog.
Study Objective
To conduct comparative evaluation of anesthetic activity of Vezotil® and Zoletil® 100 in cats and dogs, determine therapeutic equivalence and identify clinically significant differences in drug action.
Materials and Methods
Study Design
- • Randomized controlled study
- • Double-blind comparison
- • Parallel groups
- • Single-center study
- • Prospective design
Inclusion Criteria
- • Healthy animals (ASA I-II)
- • Age 1 to 8+ years
- • Body weight 2 to 45 kg
- • Elective surgical procedures
- • Informed owner consent
Anesthesia Protocol
Premedication
- • Atropine 0.02-0.04 mg/kg SC
- • 15-20 minutes before induction
- • Salivation control
Induction
- • Vezotil® or Zoletil® 100
- • Dosage 10-15 mg/kg IM
- • Single administration
Monitoring
- • HR, RR, temperature
- • Anesthesia depth
- • Recovery quality
Study Results
Key Findings
🏆 Key Results
- • Vezotil® demonstrated complete therapeutic equivalence to Zoletil® 100
- • No statistically significant differences in main anesthesia parameters
- • Vezotil® showed some advantages in sedative effect
- • Both drugs showed high safety profile
Time Characteristics
Vezotil®
Onset: 3.2±0.8 min
Duration: 62±15 min
Recovery: 95±20 min
Zoletil® 100
Onset: 3.5±0.9 min
Duration: 58±18 min
Recovery: 102±25 min
p > 0.05 for all parameters
Quality Parameters
Statistical Analysis
Statistical Methods
Tests used:
- • Student's t-test
- • Mann-Whitney U test
- • Pearson's χ² test
- • Kaplan-Meier survival analysis
Significance level:
- • α = 0.05 (p < 0.05)
- • Study power: 80%
- • Confidence interval: 95%
- • Effect size: 0.3
Key Statistical Results
📊 Statistical conclusion: Absence of statistically significant differences (p > 0.05) confirms therapeutic equivalence of the drugs.
Conclusions and Perspectives
Scientific Conclusions
1. Vezotil® demonstrated complete therapeutic equivalence to the original Zoletil® 100 across all main anesthetic activity parameters.
2. Some clinical advantages of Vezotil were identified: more pronounced sedation during induction and significantly less salivation.
3. Both drugs showed high safety profile when used at recommended dosages.
Clinical Significance
Results of this pilot study justify the possibility of using Vezotil® as an alternative to Zoletil® 100 in veterinary anesthesiological practice. This is especially important in the context of import substitution and ensuring availability of quality anesthetics for Russian veterinary clinics.
Further Research Perspectives
- • Conducting larger-scale multicenter study
- • Studying application in exotic animal species
- • Pharmacoeconomic analysis
- • Long-term safety studies
- • Comparison with other anesthetics